Each bolus contains:
Trimethoprim IP: 250 mg
Sulphamethaxazole IP: 1250 mg
MEDIPRIM bolus is used for the treatment of respiratory tract infection, G.I. tract infections, Urinary Tract infections caused by G+ve and G-ve bacteria.
Mode of Action:
Sulphamethaxazole inhibits the synthesis of Dihydrofolic Acid from PABA.
Trimethoprim acts on Dihydrofolate reductase thus Dihydrofolic Acid is not synthesized to Tetrahydrofolic Acid. Hence formation of bacterial DNA is totally arrested. This mode of action is called Double Sequential Blockade.
Dosage & Administration:
For Large Animals: 2 - 3 bolus twice daily for 3 - 5 days
For Small Animals: ½ - 1 bolus twice daily for 3 - 5 days
Strip of 4 boluses